Flumazenil

Description: Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner. Flumazenil is an imidazobenzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Target: GABA Receptor. Smiles: CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21. References: Hoffman EJ, et al. Clin Pharm, 1993, 12(9), 641-656.