Fludioxonil

Fludioxonil is a phenylpyrrole fungicide. It inhibits the growth of B. cinerea isolates from strawberry and blackberry crops (EC50s = 0.06-0.38 mg/L). Fludioxonil also inhibits the growth of S. cerevisiae AF293 and C. albicans IFO1385 in a concentration-dependent manner. It is an estrogen receptor alpha (ERalpha) agonist (EC50 = 3.7 µM in a yeast reporter assay) that induces expression of the oncogenic microRNA miR-21, inhibits estradiol-induced proliferation, and reduces cell motility of MCF-7 breast cancer cells in vitro. Formulations containing fludioxonil have been used as fungicides in agricultural, aquatic, commercial, industrial, and residential areas.Formal Name: 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile. CAS Number: 131341-86-1. Synonyms: CGA 173506. Molecular Formula: C12H6F2N2O2. Formula Weight: 248.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: FC1(F)OC2=CC=CC(C3=CNC=C3C#N)=C2O1. InChi Code: InChI=1S/C12H6F2N2O2/c13-12(14)17-10-3-1-2-8(11(10)18-12)9-6-16-5-7(9)4-15/h1-3,5-6,16H. InChi Key: MUJOIMFVNIBMKC-UHFFFAOYSA-N.