Flubendazole

Flubendazole is a benzimidazole carbamate anthelmintic. It completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. Flubendazole inhibits mammalian tubulin polymerization (IC50 = 2.5 µM) and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50 = 0.17 µM). Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC50s = 0.72, 1.51, 1.75, and 5.51 µM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.Formal Name: N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester. CAS Number: 31430-15-6. Synonyms: NSC 313680, R-17889, R-17899. Molecular Formula: C16H12FN3O3. Formula Weight: 313.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetic Acid (2%): soluble, DMSO: 1 mg/ml at 25° C, Ethanol: <1 mg/ml at 25° C, Water: <1 mg/ml at 25° C. lambdamax: 212, 249, 312 nm. SMILES: FC1=CC=C(C(C2=CC=C(N=C(NC(OC)=O)N3)C3=C2)=O)C=C1. InChi Code: InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22). InChi Key: CPEUVMUXAHMANV-UHFFFAOYSA-N.