FLLL32

FLLL32 is a cell-permeable analog of curcumin (Cay-81025) that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50 = ~5 µM). It blocks signaling from IFN-alpha or IL-6 through JAK2/STAT3 and induces apoptosis in several types of cancer cells. FLLL32 does not interfere with IFN-gamma-induced STAT1 signaling and does not adversely affect the function or viability of immune cells. Through its effects on JAK2/STAT3 signaling, FLLL32 enhances the chemo- and radiosensitivity of cancer cells.Formal Name: (2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)]-2-propen-1-one. CAS Number: 1226895-15-3. Synonyms: JAK2 Inhibitor X. Molecular Formula: C28H32O6. Formula Weight: 464.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, Ethanol: Slightly Soluble. lambdamax: 355 nm. SMILES: O=C(/C=C/C1=CC(OC)=C(OC)C=C1)C2(C(/C=C/C3=CC=C(OC)C(OC)=C3)=O)CCCCC2. InChi Code: InChI=1S/C28H32O6/c1-31-22-12-8-20(18-24(22)33-3)10-14-26(29)28(16-6-5-7-17-28)27(30)15-11-21-9-13-23(32-2)25(19-21)34-4/h8-15,18-19H,5-7,16-17H2,1-4H3/b14-10+,15-11+. InChi Key: NQDROBVIYYEMDQ-WFYKWJGLSA-N.