FINO2

Description: FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrating stability across varying pH levels. Furthermore, FINO2 induces widespread lipid peroxidation. Target: Ferroptosis. Smiles: CC(C)(C)[C@H]1CC[C@]2(CC(C)(CCO)OO2)CC1. References: Gaschler MM, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May,14(5):507-515.