Filipin Complex

Filipin complex is a neutral polyene originally isolated from S. filipinensis with antifungal activity. It inhibits cell growth as well as mitochondrial terminal electron transport in S. cerevisiae when used at a concentration of 135 µg/ml. Filipin complex binds to various sterols, particularly 24alpha-methyl cholesterol (Item no. 17344), 24alpha-ethyl cholesterol (Item no. 11756), and cholesterol, in aqueous solutions and in fungal cell membranes when used at a concentration of 50 µg/ml, inducing membrane pit formation and leakage of cell contents. It is a fluorescent compound that has been used to label sterols within biological structures for imaging. Filipin complex displays excitation/emission maxima of 338/480 nm, respectively.CAS Number: 11078-21-0. Synonyms: U-5956. Molecular Formula: C35H58O11 (for Filipin III). Formula Weight: 654.8. Purity: >95%. Emission: 480 nm. Excitation: 338 nm. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: O[C@@H]1/C(C)=C/C=C/C=C/C=C/C=C/C[C@@H](C)OC([C@@](CCCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C1)=O.O[C@@H]2/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC([C@@]([C@H](O)CCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C2)=O.O[C@@H]3/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC([C@@](CCCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C3)=O. InChi Code: InChI=1S/C35H58O11.C35H58O10.C35H58O9/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45,1-4-5-6-13-16-31-34(43)23-30(40)21-28(38)19-26(36)18-27(37)20-29(39)22-33(42)24(2)15-12-10-8-7-9-11-14-17-32(41)25(3)45-35(31)44,1-4-5-6-15-18-32-34(42)24-31(40)22-29(38)20-27(36)19-28(37)21-30(39)23-33(41)25(2)16-13-11-9-7-8-10-12-14-17-26(3)44-35(32)43/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3,7-12,14-15,17,25-34,36-43H,4-6,13,16,18-23H2,1-3H3,7-14,16,26-34,36-42H,4-6,15,17-24H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+,8-7+,11-9+,12-10+,17-14+,24-15+,9-7+,10-8+,13-11+,14-12+,25-16+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-,25-,26+,27-,28+,29-,30+,31-,32+,33+,34+,26-,27+,28-,29+,30-,31+,32-,33+,34+/m111/s1. InChi Key: IHAFZJMCJAUNQT-XPOKRYMLSA-N.