Fexofenadine (hydrochloride)

Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM). It reverses contraction of isolated rat tracheal strips induced by acetyl-beta-methylcholine (Cay-23092). Fexofenadine inhibits expression of IL-8 in TNF-alpha-stimulated HCT116 and COLO 205 cells. Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IkappaB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS, Cay-23250).Formal Name: 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-alpha,alpha-dimethyl-benzeneacetic acid, monohydrochloride. CAS Number: 153439-40-8. Synonyms: MDL 16455A. Molecular Formula: C32H39NO4 . HCl. Formula Weight: 538.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 12 mg/ml, Ethanol: 12 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(CCCC(O)C4=CC=C(C(C)(C)C(O)=O)C=C4)CC3.Cl. InChi Code: InChI=1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27,/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36),1H. InChi Key: RRJFVPUCXDGFJB-UHFFFAOYSA-N.