Fexinidazole

Fexinidazole is an antiparasitic agent. It is active against 15 strains of T. brucei, including T. b. rhodesiense, T. b. brucei, and T. b. gambiense (IC50s = 0.95-3.31 µM). Fexinidazole inhibits the growth of L. donovani at the promastigote and axenic amastigote stages (EC50s = 5.6 and 2.8 µM, respectively). Fexinidazole (50 to 30 mg/kg per day) reduces parasitic burden and increases survival in a mouse model of infection with benznidazole-susceptible, -partially resistant, or -resistant T. cruzi. Formulations containing fexinidazole have been used in the treatment of African sleeping sickness and Chagas disease.Formal Name: 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole. CAS Number: 59729-37-2. Synonyms: HOE239. Molecular Formula: C12H13N3O3S. Formula Weight: 279.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 227, 257, 299 nm. SMILES: CSC1=CC=C(OCC2=NC=C([N+]([O-])=O)N2C)C=C1. InChi Code: InChI=1S/C12H13N3O3S/c1-14-11(13-7-12(14)15(16)17)8-18-9-3-5-10(19-2)6-4-9/h3-7H,8H2,1-2H3. InChi Key: MIWWSGDADVMLTG-UHFFFAOYSA-N.