Ferulic Acid methyl ester

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid methyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid methyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 74.7 µM for ferulic acid ethyl ester vs. 44.6 µM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). Ferulic acid methyl ester, at 10-25 µg/ml, inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces nitric oxide generation from LPS-stimulated macrophages.Formal Name: 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid, methyl ester. CAS Number: 2309-07-1. Synonyms: Methyl Ferulate, Methyl 4'-hydroxy-3'-methoxycinnamate. Molecular Formula: C11H12O4. Formula Weight: 208.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 219, 237, 326 nm. SMILES: COC1=C(O)C=CC(/C=C/C(OC)=O)=C1. InChi Code: InChI=1S/C11H12O4/c1-14-10-7-8(3-5-9(10)12)4-6-11(13)15-2/h3-7,12H,1-2H3/b6-4+. InChi Key: AUJXJFHANFIVKH-GQCTYLIASA-N.