Ferulic Acid ethyl ester

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 µM for ferulic acid ethyl ester vs. 44.6 µM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid beta-peptide. Moreover, ferulic acid ethyl ester (25 µM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.Formal Name: 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid, ethyl ester. CAS Number: 4046-02-0. Synonyms: BBR 3222, NSC 14879. Molecular Formula: C12H14O4. Formula Weight: 222.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 11 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 218, 236, 326 nm. SMILES: COC1=C(O)C=CC(/C=C/C(OCC)=O)=C1. InChi Code: InChI=1S/C12H14O4/c1-3-16-12(14)7-5-9-4-6-10(13)11(8-9)15-2/h4-8,13H,3H2,1-2H3/b7-5+. InChi Key: ATJVZXXHKSYELS-FNORWQNLSA-N. Origin: Plant/Ferula communis.