Ferroptocide

Description: Ferroptocide, a thioredoxin (Trx) inhibitor and pleuromutilin derivative, exhibits inhibitory activity against Trx in ES-2 ovarian cancer cells at a concentration of 20 µM and demonstrates cytotoxicity towards these cells with an IC50 of 1.6 µM. At a dosage of 5 µM, it induces ferroptosis in ES-2 cells, which is mitigatable by the iron chelator deferoxamine (DFO), the antioxidant Trolox, or the ferroptosis inhibitor ferrostatin-1. Furthermore, it effectively reduces tumor volume in a 4T1 murine mammary carcinoma model with immunocompetent mice, but not in immunodeficient mice, when administered at 50 mg/kg bi-weekly. Target: Others. Smiles: O=C(N1CC([C@H](C[C@@H](OC(CCl)=O)[C@]23C)[C@@H]([C@@]([C@]3(C([C@H]4O)=O)O)(C4)CC[C@H]2C)C)=CCN15)N(C6=CC=CC=C6)C5=O