Fascaplysin chloride

Description: Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 µM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells. Target: Others. Smiles: [Cl-].O=C1C2=C(C=CC=C2)[N+]2=C1C1=C(C=C2)C2=CC=CC=C2N1. References: Mischitelli M, Jemaà M, Almasry M, Faggio C, Lang F. Triggering of Suicidal Erythrocyte Death by Fascaplysin. Cell Physiol Biochem. 2016,39(4):1638-47. doi: 10.1159/000447865. PubMed PMID: 27626793.