FAK inhibitor 6

Description: Compound 26F effectively optimizes enzyme inhibition (IC50 = 28.2 nM) while demonstrating relatively low cytotoxicity (IC50 = 3.32 µM). It induces apoptosis in MDA-MB-231 cells in a dose-dependent manner and efficiently arrests these cells in the G0/G1 phase. Target: Others. Smiles: N(C=1N=C2C(=CSC2=CN1)C3=C(OC)C=CC=C3)C4=CC(F)=C(C(NC5CCNCC5)=O)C=C4