Ezutromid

Ezutromid is a modulator of utrophin production. It upregulates utrophin production in mouse myoblasts (EC50 = 0.91 µM in a reporter assay). It inhibits the activity of the cytochrome P450 (CYP) isoform CYP1A2 in pooled human liver microsomes (IC50 = 5.4 µM). Chronic administration of ezutromid (50 mg/kg) increases utrophin protein levels in the heart, increases grip strength, and decreases fatigue, indicated by distance traveled during forced exercise, in the mdx mouse model of muscular dystrophy.Formal Name: 5-(ethylsulfonyl)-2-(2-naphthalenyl)-benzoxazole. CAS Number: 945531-77-1. Synonyms: BMN 195, SMT-C1100, VOX-C1100. Molecular Formula: C19H15NO3S. Formula Weight: 337.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 3 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 236, 255, 262, 314 nm. SMILES: CCS(C1=CC=C2C(N=C(C3=CC(C=CC=C4)=C4C=C3)O2)=C1)(=O)=O. InChi Code: InChI=1S/C19H15NO3S/c1-2-24(21,22)16-9-10-18-17(12-16)20-19(23-18)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,2H2,1H3. InChi Key: KSGCNXAZROJSNW-UHFFFAOYSA-N.