Etoposide

Description: Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 µM). Etoposide has antitumor activity and induces apoptosis and autophagy. Target: Autophagy, Antibacterial, Apoptosis, Mitophagy, Antibiotic, Topoisomerase. Smiles: O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@H](C)OC5)[H])[H])[C@]2(CO1)[H])=CC6=C(C3)OCO6)C7=CC(OC)=C(O)C(OC)=C7)[H]. References: HGN ÇELEBIOGLU, et al. Effects of thymoquinone and etoposide combination on cell viability and genotoxicity in human cervical cancer hela cells. Istanbul J Pharm. 2022, 52(3):258-264.