ESI-05

ESI-05 is an inhibitor of exchange protein activated by cAMP 2 (Epac2) that inhibits cAMP-induced Epac2 guanine nucleotide exchange factor (GEF) activity with an IC50 value of 0.43 µM in a cell-free assay. It is selective for Epac2 over Epac1 and PKA at 25 µM. ESI-05 (1, 5, 10, and 25 µM) reduces activation of the GTPase RAP1 induced by the Epac-selective cAMP analog 007-AM in HEK293 cells expressing Epac2 but has no effect in HEK293 cells expressing Epac1.Formal Name: 1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-benzene. CAS Number: 5184-64-5. Synonyms: NSC 116966. Molecular Formula: C16H18O2S. Formula Weight: 274.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 243 nm. SMILES: CC1=C(S(C2=CC=C(C)C=C2)(=O)=O)C(C)=CC(C)=C1. InChi Code: InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3. InChi Key: CGPHOZWFSFNOEQ-UHFFFAOYSA-N.