Eriocitrin

Eriocitrin is a flavonoid originally isolated from lemon peel that has antioxidant and enzyme inhibitory activity. Eriocitrin inhibits lipid peroxidation in a cell-free assay when used at a concentration of 10 µM and enhances the effect of alpha-tocopherol (Cay-25985) on lipid peroxidation. It also decreases thiobarbituric acid reactive substances (TBARS) in rat plasma when administered at a dose of 75 µmol/kg, indicating a reduction in lipid peroxidation. Eriocitrin prevents acute exercise-induced increases in TBARS, Nepsilon-(hexanoyl)lysine (HEL), o,o-dityrosine (DT), and nitrotyrosine (NT, Cay-89540) in rat liver when administered at a dose of 600 mg/kg prior to exercise. It is also an inhibitor of monoamine oxidase A (MAO-A) and MAO-B (IC50s = 86.5 and 164 µM, respectively, for human recombinant receptors).Formal Name: (2S)-7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5-hydroxy-4H-1-benzopyran-4-one. CAS Number: 13463-28-0. Synonyms: Eriodictioside, Eriodictyol 7-O-rutinoside. Molecular Formula: C27H32O15. Formula Weight: 596.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 1 mg/ml. lambdamax: 284 nm. SMILES: O[C@H]1[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)O[C@@H](OC3=CC(O)=C(C(C[C@@H](C4=CC=C(O)C(O)=C4)O5)=O)C5=C3)[C@@H]1O. InChi Code: InChI=1S/C27H32O15/c1-9-20(32)22(34)24(36)26(39-9)38-8-18-21(33)23(35)25(37)27(42-18)40-11-5-14(30)19-15(31)7-16(41-17(19)6-11)10-2-3-12(28)13(29)4-10/h2-6,9,16,18,20-30,32-37H,7-8H2,1H3/t9-,16-,18+,20-,21+,22+,23-,24+,25+,26+,27+/m0/s1. InChi Key: OMQADRGFMLGFJF-MNPJBKLOSA-N.