Ergoloid (mesylates)

Ergoloid is a mixture of the ergot alkaloids dihydroergocornine, dihydroergocrystine, and dihydroergocryptine. It blocks reflex vasodilation and vasoconstriction induced by norepinephrine (Cay-16673) in dogs when injected into the kidney at a dose of 0.15 mg. Ergoloid blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner. It also acts as an erectogenic agent in rats. Formulations containing ergoloid have been used in the treatment of migraine headaches and vascular dementias.Formal Name: dihydro-ergotoxine, monomethanesulfonate. CAS Number: 8067-24-1. Molecular Formula: C134H184N20O32S4. Formula Weight: 2715.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: 1 mg/ml. SMILES: [H][C@@]12[C@](C3=C4C(C2)=CNC4=CC=C3)([H])C[C@@H](C(N[C@@]5(C(C)C)C(N([C@@H](C(C)C)C(N6[C@@]7([H])CCC6)=O)[C@@]7(O)O5)=O)=O)CN1C.[H][C@@]89[C@](C%10=C%11C(C9)=CNC%11=CC=C%10)([H])C[C@@H](C(N[C@@]%12(C(C)C)C(N([C@@H](CC%13=CC=CC=C%13)C(N%14[C@@]%15([H])CCC%14)=O)[C@@]%15(O)O%12)=O)=O)CN8C.[H][C@@]%16%17[C@](C%18=C%19C(C%17)=CNC%19=CC=C%18)([H])C[C@@H](C(N[C@@]%20(C(C)C)C(N([C@@H](CC(C)C)C(N%21[C@@]%22([H])CCC%21)=O)[C@@]%22(O)O%20)=O)=O)CN%16C.[H][C@@]%23%24[C@](C%25=C%26C(C%24)=CNC%26=CC=C%25)([H])C[C@@H](C(N[C@@]%27(C(C)C)C(N([C@]([C@](C)([H])CC)([H])C(N%28[C@@]%29([H])CCC%28)=O)[C@@]%29(O)O%27)=O)=O)CN%23C.OS(C)(=O)=O.OS(C)(=O)=O.OS(C)(=O)=O.OS(C)(=O)=O. InChi Code: InChI=1S/C35H41N5O5.2C32H43N5O5.C31H41N5O5.4CH4O3S/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34,1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20,1-6-18(4)27-29(39)36-12-8-11-25(36)32(41)37(27)30(40)31(42-32,17(2)3)34-28(38)20-13-22-21-9-7-10-23-26(21)19(15-33-23)14-24(22)35(5)16-20,1-16(2)26-28(38)35-11-. InChi Key: PBKVEOSEPXMKDN-HJMQKNHVSA-N.