ERGi-USU

ERGi-USU is an inhibitor of the oncoprotein ETS-related gene (ERG, IC50 = 315 nM). It inhibits proliferation of ERG-expressing VCaP prostate, COLO 320 colon, and KG-1 and MOLT-4 leukemia cancer cells (IC50s = 30-400 nM) but not LNCaP, LAPC4, and MDA PCa 2b prostate cancer and human umbilical vein endothelial cells (HUVECs), which do not express ERG (IC50s = >10 µM for all). ERGi-USU (100 and 150 mg/kg) reduces tumor growth in a VCaP mouse xenograft model.Formal Name: 1-[2-(2-thiazolyl)diazenyl]-2-naphthalenol. CAS Number: 1147-56-4. Synonyms: NSC 139021. Molecular Formula: C13H9N3OS. Formula Weight: 255.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15mg/mL, DMSO: 5mg/mL, Ethanol: 0.5mg/mL. lambdamax: 213, 226, 482 nm. SMILES: OC1=C(/N=N/C2=NC=CS2)C(C=CC=C3)=C3C=C1. InChi Code: InChI=1S/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8,17H/b16-15+. InChi Key: IOMXCGDXEUDZAK-FOCLMDBBSA-N.