Erdosteine

Erdosteine is a mucolytic agent and an antioxidant. It inhibits LPS-induced IkappaB kinase (IKK) activity, NF-kappaB-mediated transcription, and production of IL-6 and IL-1beta in RAW 264.7 cells. Erdosteine (7.5 mg/kg) prevents depletion of renal catalase and glutathione peroxidase (GPX) and increases in renal malondialdehyde (MDA) and nitric oxide (NO) levels in a rat model of nephrotoxicity induced by cisplatin (Cay-13119). It reduces spinal cord lipid peroxidation and destruction of spinal motor neurons in a rabbit model of spinal cord ischemia and reperfusion injury induced by thoracoabdominal aortic clamping. Erdosteine (150 mg/kg) reduces lung weight, MDA and protein carbonyl levels, and macrophage and neutrophil accumulation in a mouse model of acute lung injury induced by oleic acid (Cay-90260, Cay-24659). Formulations containing erdosteine have been used in the treatment of chronic obstructive pulmonary disease (COPD).Formal Name: 2-[[2-oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]-acetic acid. CAS Number: 84611-23-4. Synonyms: Erdostin. Molecular Formula: C8H11NO4S2. Formula Weight: 249.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml. lambdamax: 235 nm. SMILES: O=C(CSCC(O)=O)NC1C(SCC1)=O. InChi Code: InChI=1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12). InChi Key: QGFORSXNKQLDNO-UHFFFAOYSA-N.