Epiblastin A

Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms alpha, delta, and epsilon (IC50s = 8.9, 0.5, and 4.7 µM, respectively). It is selective for CK1alpha, CK1delta, and CK1epsilon at concentrations below 10 µM, however, it also inhibits BRSK1, EEF2K, EGFR, MNK-2, and RIPK2 (IC50s = 24-45 µM). Epiblastan A reduces immunoprecipitation of CK1alpha, CK1delta, and CK1epsilon from HCT116 cell lysates in a concentration-dependent manner. It induces reprogramming of mouse epiblast stem cells (mEpiSCs) into embryonic stem cells (ESCs) 8-fold more efficiently than triamterene (Cay-21242, Cay-22486).Formal Name: 6-(3-chlorophenyl)-2,4,7-pteridinetriamine. CAS Number: 16470-02-3. Molecular Formula: C12H10ClN7. Formula Weight: 287.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. SMILES: NC1=NC2=NC(N)=NC(N)=C2N=C1C3=CC(Cl)=CC=C3. InChi Code: InChI=1S/C12H10ClN7/c13-6-3-1-2-5(4-6)7-9(14)18-11-8(17-7)10(15)19-12(16)20-11/h1-4H,(H6,14,15,16,18,19,20). InChi Key: ZWNKKZSRANLVEW-UHFFFAOYSA-N.