Enrofloxacin-d5

Enrofloxacin-d5 is intended for use as an internal standard for the quantification of enrofloxacin (Cay-20301) by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic. It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml). Enrofloxacin inhibits bacterial DNA gyrase. In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model of enteropathogenic E. coli-induced sepsis. Formulations containing enrofloxacin have been used in the treatment of veterinary bacterial infections.Formal Name: 1-cyclopropyl-7-[4-(ethyl-1,1,2,2,2-d5)-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid. CAS Number: 1173021-92-5. Synonyms: BAY-Vp 2674-d5, ENR-d5. Molecular Formula: C19H17D5FN3O3. Formula Weight: 364.4. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 1 mg/ml. lambdamax: 284 nm. SMILES: O=C1C2=CC(F)=C(N3CCN(CC3)C([2H])([2H])C([2H])([2H])[2H])C=C2N(C4CC4)C=C1C(O)=O. InChi Code: InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)/i1D3,2D2. InChi Key: SPFYMRJSYKOXGV-ZBJDZAJPSA-N.