Enoxacin-d8 (hydrochloride)

Enoxacin-d8 is intended for use as an internal standard for the quantification of enoxacin (Cay-16956) by GC- or LC-MS. Enoxacin is a fluoroquinolone antibiotic. It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria, including S. aureus, E. coli, K. pneumoniae, P. aeruginosa, and S. marcescens (MIC50s = 1, 0.12, 0.25, 0.5, and 1 mg/L, respectively). Enoxacin inhibits S. aureus DNA gyrase supercoiling activity and topoisomerase IV DNA decatenation (IC50s = 126 and 26.5 µg/ml, respectively). It increases survival in mouse models of systemic S. aureus, E. coli, K. pneumoniae, P. aeruginosa, and S. marcescens infection with ED50 values of 15.1, 2.2, 4.1, 120.3, and 7.6 mg/kg, respectively. Enoxacin (4 and 8 mg/kg per day) also reduces tumor growth in a 143B human osteosarcoma mouse xenograft model. Formulations containing enoxacin have previously been used in the treatment of urinary tract infections and gonorrhea.Formal Name: 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl-2,2,3,3,5,5,6,6-d8)-1,8-naphthyridine-3-carboxylic acid, monohydrochloride. CAS Number: 2930288-95-0. Molecular Formula: C15H9D8FN4O3 . HCl. Formula Weight: 364.8. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: DMSO: warmed, Water: soluble. SMILES: CCN1C2=NC(N3C([2H])([2H])C([2H])([2H])NC([2H])([2H])C3([2H])[2H])=C(F)C=C2C(C(C(O)=O)=C1)=O.Cl. InChi Code: InChI=1S/C15H17FN4O3.ClH/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20,/h7-8,17H,2-6H2,1H3,(H,22,23),1H/i3D2,4D2,5D2,6D2,. InChi Key: ODOAWCIYUUFLHN-JCYLEXHWSA-N.