Enmetazobactam

Enmetazobactam is a beta-lactamase inhibitor. It has greater activity against class A beta-lactamases (IC50s = 0.006-0.52 µM) than class B or class D beta-lactamases (IC50s = 8.7->100 µM). Enmetazobactam in combination with the cephalosporin antibiotic cefepime (Cay-23633) is active against 223 Enterobacteriaceae clinical isolates, including multidrug-resistant E. coli and K. pneumoniae isolates, with an MIC50 value of 0.125 mg/L. In vivo, enmetazobactam reduces mortality in mouse models of septicemia induced by E. coli, K. pneumoniae, or E. cloacae when used in combination with cefepime.Formal Name: 3-[[(2S,3S,5R)-2-carboxy-3-methyl-4,4-dioxido-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-3-yl]methyl]-1-methyl-1H-1,2,3-triazolium, inner salt. CAS Number: 1001404-83-6. Synonyms: AAI-101. Molecular Formula: C11H14N4O5S. Formula Weight: 314.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C1C[C@]2([H])N1[C@@H](C([O-])=O)[C@@](C[N+]3=NN(C)C=C3)(C)S2(=O)=O. InChi Code: InChI=1S/C11H14N4O5S/c1-11(6-14-4-3-13(2)12-14)9(10(17)18)15-7(16)5-8(15)21(11,19)20/h3-4,8-9H,5-6H2,1-2H3/t8-,9+,11+/m1/s1. InChi Key: HFZITXBUTWITPT-YWVKMMECSA-N.