Endoxifen

Description: (E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment. Target: Drug Metabolite, Parasite, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Aromatase. Smiles: CC\C(=C(\c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1. References: Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park). 2009 Dec,23(14):1233-4, 1236.