Emodin

Yellow Powder Soluble in DMSO (10mg/ml) or 100% ethanol. Insoluble in water. Chemical. CAS: 518-82-1. Formula: C15H10O5. MW: 270.24. Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. It displays anti-inflammatory, antitumor, neuroprotective, antioxidant and anti-diabetic properties. At a molecular level, Emodin inhibits casein kinase II, p56lck, NF-kappaB, 11beta-HSD1, Estrogen receptor ERalpha and ERbeta, androgen receptor (AR) nuclear translocation, VEGFR2, FGFR-1, EGFR, PDGFR-beta, Kit and JAK2. It has also been described to inhibit the inflammasome, being a AMPK activator and PPARgamma agonist and a P2X7 receptor antagonist.