Emodin

Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. Purified emodin has diverse effects, including the suppression of inflammation, dyslipidemia, and cancer. At a molecular level, emodin directly and selectively inhibits casein kinase II (IC50 = 0.89 µM). Through this action, it inhibits the COP9 signalosome, causing the stabilization of the tumor suppressor p53. Moreover, emodin acts as a phytoestrogen, binding human estrogen receptors and blocking 17beta-estradiol binding with Ki values of 0.77 and 1.5 µM for ERalpha and ERbeta, respectively.Formal Name: 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione. CAS Number: 518-82-1. Synonyms: Archin, Frangulic Acid, NSC 408120, NSC 622947, Schuttgelb. Molecular Formula: C15H10O5. Formula Weight: 270.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH7.2) (1:30): 0.03 mg/ml, DMSO: 3 mg/ml. lambdamax: 222, 252, 266, 290, 437 nm. SMILES: OC1=CC(C)=CC2=C1C(C3=C(O)C=C(O)C=C3C2=O)=O. InChi Code: InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3. InChi Key: RHMXXJGYXNZAPX-UHFFFAOYSA-N.