EM574

EM574 is a motilin receptor agonist with an IC50 value of 6.17 nM for binding to rabbit gastric antral smooth muscle homogenates in a radioligand binding assay. It also binds to human smooth muscle homogenates in a radioligand binding assay (Kd = 7.8 nM). EM574 induces contraction of isolated rabbit, but not rat or guinea pig, intestine (EC50 = 5.5 nM). It increases antral motility and enhances gastric emptying in canine models of gastroparesis when administered intraduodenally at a dose of 0.03 mg/kg following a semi-solid meal.Formal Name: 8,9-didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin. CAS Number: 110480-13-2. Synonyms: Idremcinal. Molecular Formula: C39H69NO12. Formula Weight: 744.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: CC[C@H]([C@](O)(C)[C@H](O)[C@@H](C)C1=C(C)C[C@](O1)(C)[C@]([H])(O[C@@]2([H])[C@H](O)[C@@H](N(C(C)C)C)C[C@@H](C)O2)[C@@H](C)[C@@](O[C@]3([H])O[C@@H](C)[C@H](O)[C@](C)(OC)C3)([H])[C@H]4C)OC4=O. InChi Code: InChI=1S/C39H69NO12/c1-15-27-39(12,45)32(42)22(6)30-20(4)17-38(11,52-30)34(51-36-29(41)26(16-21(5)47-36)40(13)19(2)3)23(7)31(24(8)35(44)49-27)50-28-18-37(10,46-14)33(43)25(9)48-28/h19,21-29,31-34,36,41-43,45H,15-18H2,1-14H3/t21-,22+,23+,24-,25+,26+,27-,28+,29-,31+,32-,33+,34-,36+,37-,38-,39-/m1/s1. InChi Key: FPBKIOZMKHHNLL-CBUZSSJJSA-N.