Elsibucol

Description: Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury. Target: Antioxidant. Smiles: O(CCCC(O)=O)C1=C(C(C)(C)C)C=C(SC(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)(C)C)C=C1C(C)(C)C. References: Dussault S, et al. Elsibucol inhibits atherosclerosis following arterial injury: multifunctional effects on cholesterol levels, oxidative stress and inflammation. Atherosclerosis. 2014 Nov,237(1):194-9.