Elaiophylin

Elaiophylin is a macrodiolide antibiotic that can be isolated from various strains of Streptomyces. It displays in vitro anti-protozoal activity against both Plasmodium and Trypanosoma (IC50s = 370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 = 870 ng/ml). Elaiophylin alone has no activity against Candida, although it enhances the anti-fungal activity of rapamycin (Cay-13346). Elaiophylin also forms stable, long-lasting ion channels in bilayer membranes that are selective for cations.CAS Number: 37318-06-2. Synonyms: Azalomycin-B, Gopalamicin, Salbomycin. Molecular Formula: C54H88O18. Formula Weight: 1025.3. Purity: >95%. Formulation: (Request formulation change), A neat solid. Solubility: DMSO: 20 mg/ml, Ethanol: 1 mg/ml *. lambdamax: 253 nm. SMILES: CC[C@H]1[C@@H](C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@](OC(/C=C/C=C/[C@H](C)[C@]([C@@H](C)[C@@H](O)[C@@H]([C@@](C[C@H]2O[C@@](O[C@@H](C)[C@H]3O)([H])C[C@@H]3O)(O[C@H](C)[C@H]2CC)O)C)([H])O4)=O)([H])[C@H](/C=C/C=C/C4=O)C)C)(O)O[C@@H]1C)O[C@@](O[C@@H](C)[C@H]5O)([H])C[C@@H]5O. InChi Code: InChI=1S/C54H88O18/c1-13-37-33(9)71-53(63,25-41(37)67-45-23-39(55)49(61)35(11)65-45)31(7)47(59)29(5)51-27(3)19-15-17-22-44(58)70-52(28(4)20-16-18-21-43(57)69-51)30(6)48(60)32(8)54(64)26-42(38(14-2)34(10)72-54)68-46-24-40(56)50(62)36(12)66-46/h15-22,27-42,45-52,55-56,59-64H,13-14,23-26H2,1-12H3/b19-15+,20-16+,21-18+,22-17+/t27-,28-,29-,30-,31-,32-,33+,34+,35-,36-,37+,38+,39-,40-,41+,42+,45-,46-,47+,48+,49+,50+,51-,52-,53+,54+/m0/s1. InChi Key: OSERMIPXNLXAPD-MJMYBOKFSA-N. Origin: Bacterium/Streptomyces hygroscopicus.