EHNA hydrochloride

Description: EHNA hydrochloride is a chemical compound recognized for its antiviral, antitumor, and antiarrhythmic properties. It functions as a potent and selective inhibitor of both cyclic nucleotide phosphodiesterase 2 (PDE2) with an IC50 of 4 µM and adenosine deaminase (ADA). Additionally, it effectively inhibits the activity of cGMP-stimulated PDE II (cGs-PDE) with IC50 values of 0.8 µM in humans and 2 µM in porcine myocardium, although its inhibitory effects on unstimulated PDE2 activity are less pronounced. Target: Others. Smiles: Cl.CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12. References: Podzuweit T, et al. Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine.Cell Signal. 1995 Sep,7(7):733-8.