EHNA (hydrochloride)

EHNA is a reversible adenosine deaminase inhibitor (IC50 = 1.2 µM in human red blood cells) that also selectively inhibits the cGMP-specific phosphodiesterase (PDE2) (IC50s = 0.8 and 2 µM from human and porcine myocardium, respectively, 3.5 µM in rat hepatocyte, and 5.5 µM in human platelet). Comparatively, EHNA is much less potent at inhibiting PDE1, PDE3, or PDE4 (IC50s > 100 µM). EHNA has been used to evaluate cardioprotective and neuroprotective effects during ischemia, to study the role of cAMP/cGMP signaling, and to maintain pluripotency/prevent differentiation of human embryonic stem cells.Formal Name: (alphaR,betaS)-rel-6-amino-beta-hexyl-alpha-methyl-9H-purine-9-ethanol, monohydrochloride. CAS Number: 58337-38-5. Synonyms: NSC 263164, erythro-9-(2-Hydroxy-3-nonyl)adenine. Molecular Formula: C14H23N5O . HCl. Formula Weight: 313.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml, Water: 10 mg/ml. lambdamax: 210, 261 nm. SMILES: NC1=C2C(N([C@@H](CCCCCC)[C@H](O)C)C=N2)=NC=N1.Cl. InChi Code: InChI=1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19,/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17),1H/t10-,11+,/m1./s1. InChi Key: VVDXNJRUNJMYOZ-DHXVBOOMSA-N.