Edotecarin

Description: Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM). Target: Topoisomerase. Smiles: O=C1C2=C3C(N(C=4C3=CC=C(O)C4)[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)=C6C(=C2C(=O)N1NC(CO)CO)C=7C(N6)=CC(O)=CC7. References: Saif MW, et al. Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May,5(1):27-36.