DYRK1A Inhibitor Compound 11

DYRK1A inhibitor compound 11 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A, IC50 = 0.4 nM). It is selective for DYRK1A over DYRK2, CDC-like kinase 1 (Clk1), Clk2, Clk3, cyclin-dependent kinase 2 (Cdk2), and glycogen synthase kinase 3beta (GSK3beta, IC50s = 19, 7.1, 9.4, 54, 100, and 94 nM, respectively) but does inhibit DYRK1B (IC50 = 2.7 nM). DYRK1A inhibitor compound 11 inhibits DYRK1A-induced increases in tau phosphorylation in a cell-based assay (IC50 = 590 nM).Formal Name: N,N-dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinamine. CAS Number: 2814486-79-6. Synonyms: Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A Inhibitor Compound 11, DYRK1-IN-1, DYRK1 Inhibitor 1. Molecular Formula: C12H12N6. Formula Weight: 240.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble: 1-10 mg/ml, Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: CN(C)C1=NC=CC(C2=C3N(N=CC=C3)N=C2)=N1. InChi Code: InChI=1S/C12H12N6/c1-17(2)12-13-7-5-10(16-12)9-8-15-18-11(9)4-3-6-14-18/h3-8H,1-2H3. InChi Key: IFLBFWBMAWIBBZ-UHFFFAOYSA-N.