Dynasore

Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 µM). Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as particles and receptor ligands. In some cases, dynasore can also augment the release of neurotransmitters and secreted cytokines.Formal Name: 3-hydroxy-2-[(3,4-dihydroxyphenyl)methylene]hydrazide-2-naphthalenecarboxylic acid. CAS Number: 304448-55-3. Molecular Formula: C18H14N2O4. Formula Weight: 322.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 12.5 mg/ml. SMILES: OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=CC(O)=C(O)C=C3)=O. InChi Code: InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+. InChi Key: SYNDQCRDGGCQRZ-VXLYETTFSA-N.