Dxd

Dxd is a derivative of the DNA topoisomerase I inhibitor exatecan (Cay-35452) and a starting material that has been used in the synthesis of antibody-drug conjugates (ADCs). It has been used in the synthesis of ADCs targeting HER2 with anticancer activity in vitro and in vivo.Formal Name: N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxy-acetamide. CAS Number: 1599440-33-1. Molecular Formula: C26H24FN3O6. Formula Weight: 493.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: OCC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O. InChi Code: InChI=1S/C26H24FN3O6/c1-3-26(35)15-6-19-23-13(8-30(19)24(33)14(15)10-36-25(26)34)22-17(28-20(32)9-31)5-4-12-11(2)16(27)7-18(29-23)21(12)22/h6-7,17,31,35H,3-5,8-10H2,1-2H3,(H,28,32)/t17-,26-/m0/s1. InChi Key: PLXLYXLUCNZSAA-QLXKLKPCSA-N.