DSS Crosslinker

Description: DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins. Target: Others, ADC Linker. Smiles: O(C(CCCCCCC(ON1C(=O)CCC1=O)=O)=O)N2C(=O)CCC2=O. References: Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May,16(5):315-337.