DSM 265

DSM 265 is an antimalarial agent and inhibitor of P. falciparum and P. vivax dihydroorotate dehydrogenase (DHODH, IC50s = 8.9 and 27 nM, respectively). It is selective for P. falciparum and P. vivax DHODH over human, rabbit, pig, and monkey DHODH (IC50s = >41 µg/ml) but does inhibit P. cynomolgi, dog, mouse, and rat DHODH (IC50s = 0.005, 11, 1.1, and 0.82 µg/ml, respectively). DSM 265 inhibits the growth of the P. falciparum strain 3D7 with an EC50 value of 4.3 nM. It also reduces blood parasitemia in mice (ED90 = 1.5 mg/kg twice per day).Formal Name: (OC-6-21)-[4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]pentafluoro-sulfur. CAS Number: 1282041-94-4. Molecular Formula: C14H12F7N5S. Formula Weight: 415.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: CC1=NC2=NC(C(F)(F)C)=NN2C(NC3=CC=C(C=C3)S(F)(F)(F)(F)F)=C1. InChi Code: InChI=1S/C14H12F7N5S/c1-8-7-11(26-13(22-8)24-12(25-26)14(2,15)16)23-9-3-5-10(6-4-9)27(17,18,19,20)21/h3-7,23H,1-2H3. InChi Key: OIZSVTOIBNSVOS-UHFFFAOYSA-N.