Dotinurad

Description: Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 µM for uric acid). Target: OAT. Smiles: C(=O)(N1C=2C(S(=O)(=O)C1)=CC=CC2)C3=CC(Cl)=C(O)C(Cl)=C3. References: Li X, et al. Pharmacological urate-lowering approaches in chronic kidney disease. Eur J Med Chem. 2019 Mar 15,166:186-196.