Dorzagliatin

Description: Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic beta-cell function in type 2 diabetes. Target: Glucokinase. Smiles: CC(C)C[C@H](N1CC(Oc2ccccc2Cl)=CC1=O)C(=O)Nc1ccn(C[C@@H](O)CO)n1. References: Zhu XX, et al. Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic beta-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection. Diabetes Obes Metab. 2018 Sep,20(9):2113-2120.