DOPAL

DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase. It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET, Cay-70604). DOPAL is toxic to neurons. It can also oligomerize and precipitate alpha-synuclein, an event associated with Parkinson's disease. Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson's disease.Formal Name: 3,4-dihydroxy-benzeneacetaldehyde. CAS Number: 5707-55-1. Molecular Formula: C8H8O3. Formula Weight: 152.1. Purity: >90%. Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 15 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: OC1=C(O)C=CC(CC([H])=O)=C1. InChi Code: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2. InChi Key: IADQVXRMSNIUEL-UHFFFAOYSA-N.