DMAT

DMAT is a cell-permeable inhibitor of casein kinase 2 (CK2, IC50 = 0.13 µM). It also inhibits Pim-1, Pim-3, HIPK2, and HIPK3 (IC50s = 0.15, 0.097, 0.37, and 0.59 µM, respectively). DMAT blocks cell growth and induces cell death in cancer cells, both in culture and in mouse xenografts.Formal Name: 4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine. CAS Number: 749234-11-5. Synonyms: Casein Kinase II Inhibitor II, 2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole. Molecular Formula: C9H7Br4N3. Formula Weight: 476.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml, DMSO: 20 mg/ml. lambdamax: 239, 271, 315 nm. SMILES: BrC1=C2C(NC(N(C)C)=N2)=C(Br)C(Br)=C1Br. InChi Code: InChI=1S/C9H7Br4N3/c1-16(2)9-14-7-5(12)3(10)4(11)6(13)8(7)15-9/h1-2H3,(H,14,15). InChi Key: SLPJGDQJLTYWCI-UHFFFAOYSA-N.