DL-Sulforaphane N-acetyl-L-cysteine

DL-Sulforaphane N-acetyl-L-cysteine
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay16098-1 1 mg -

6 - 10 Werktage*

61,00 €
Cay16098-5 5 mg -

6 - 10 Werktage*

264,00 €
Cay16098-10 10 mg -

6 - 10 Werktage*

466,00 €
 
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene... mehr
Produktinformationen "DL-Sulforaphane N-acetyl-L-cysteine"
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major metabolite of SFN (Cay-10496), a powerful inducer of chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression. At 75 µM, SFN-NAC has been shown to increase ARE expression in HepG2-C8 cells. Its reported potency on ARE-related gene expression is roughly 8-fold less than SFN.Formal Name: N-acetyl-S-[[[4-(methylsulfinyl)butyl]amino]thioxomethyl]-L-cysteine. CAS Number: 334829-66-2. Synonyms: SFN-NAC. Molecular Formula: C11H20N2O4S3. Formula Weight: 340.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 250, 275 nm. SMILES: OC([C@@H](NC(C)=O)CSC(NCCCCS(C)=O)=S)=O. InChi Code: InChI=1S/C11H20N2O4S3/c1-8(14)13-9(10(15)16)7-19-11(18)12-5-3-4-6-20(2)17/h9H,3-7H2,1-2H3,(H,12,18)(H,13,14)(H,15,16)/t9-,20?/m0/s1. InChi Key: IIHBKTCHILXGOT-KMYGYIBBSA-N.
Schlagworte: SFN-NAC, N-acetyl-S-[[[4-(methylsulfinyl)butyl]amino]thioxomethyl]-L-cysteine
Hersteller: Cayman Chemical
Hersteller-Nr: 16098

Eigenschaften

Anwendung: Sulforaphane metabolite, Nrf2 activator, ARE gene expression inducer
MW: 340.5 D
Formel: C11H20N2O4S3
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 334829-66-2| Passende Produkte
KEGG ID : K05638 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H315, H319, H335
P-Sätze: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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