Divalproex Sodium

Description: Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor, Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels. Target: HDAC. Smiles: [Na+].CCCC(CCC)C(O)=O.CCCC(CCC)C([O-])=O. References: Wang W, et al. Cancer Lett, 2015, 356(2 Pt B), 791-799.