Disopyramide

Description: Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. Target: Sodium Channel, AChR, Potassium Channel. Smiles: CC(C)N(CCC(C(N)=O)(c1ccccc1)c1ccccn1)C(C)C. References: Sugao M, et al. J Cardiovasc Pharmacol. 2005 Jun,45(6):545-9.