Diphenhydramine (hydrochloride)

Diphenhydramine (DPH) is a first generation antihistamine that is a potent antagonist of the histamine H1 receptor (Ki = 11.7 nM using human recombinant receptors). DPH readily crosses the blood-brain barrier and produces diverse cognitive and psychomotor effects. DPH also antagonizes muscarinic cholinergic receptors (Kis = 100 to 260 nM for M1-M5), increasing the range of central nervous system effects and applications. This product is also available as an analytical reference standard (Cay-22489).Formal Name: 2-(diphenylmethoxy)-N,N-dimethyl-ethanamine, monohydrochloride. CAS Number: 147-24-0. Synonyms: DPH. Molecular Formula: C17H21NO . HCl. Formula Weight: 291.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl. InChi Code: InChI=1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16,/h3-12,17H,13-14H2,1-2H3,1H. InChi Key: PCHPORCSPXIHLZ-UHFFFAOYSA-N.