Diminutol

Description: Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to destabilize microtubules and disrupt mitosis. At 50 µM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization. Target: Others. Smiles: S(C1=C2C(N(C(C)C)C=N2)=NC(N[C@H](C(C)C)CO)=N1)C3=CC(N)=CC=C3