Diminutol

Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to destabilize microtubules and disrupt mitosis. At 50 µM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.Formal Name: (2R)-2-[[6-[(3-aminophenyl)thio]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol. CAS Number: 361431-33-6. Synonyms: NG72. Molecular Formula: C19H26N6OS. Formula Weight: 386.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 226, 249, 324 nm. SMILES: CC(C)N1C2=NC(N[C@@H](CO)C(C)C)=NC(SC3=CC=CC(N)=C3)=C2N=C1. InChi Code: InChI=1S/C19H26N6OS/c1-11(2)15(9-26)22-19-23-17-16(21-10-25(17)12(3)4)18(24-19)27-14-7-5-6-13(20)8-14/h5-8,10-12,15,26H,9,20H2,1-4H3,(H,22,23,24)/t15-/m0/s1. InChi Key: NLQYQPZBKDUXKS-HNNXBMFYSA-N.