Dimebolin

Dimebolin is a neuroprotective agent. It binds to histamine H1 and H2 receptors (IC50s = 3.8 and 287 nM, respectively), as well as alpha1A-, alpha1B-, alpha1D-, and alpha2A-adrenergic receptors (ARs), imidazoline I2 receptors, and the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 8-313 nM). It also inhibits NMDA-evoked currents and voltage-gated calcium channels in mouse primary striatal neurons (IC50s = 10 and 50 µM, respectively). Dimebolin (50 µM) inhibits glutamate-induced apoptosis in primary striatal neurons derived from the YAC128 transgenic mouse model of Huntington's disease. It inhibits cell death induced by amyloid-beta (25-35) (Cay-24155) in cerebellar granule cells when used at a concentration of 25 µM. Dimebolin (1 mg/kg) inhibits decreases in two-way active avoidance reaction (TWAA) acquisition in a rat model of Alzheimer's disease induced by 1-ethyl-1-(2-hydroxyethyl) aziridinium (AF64A).Formal Name: 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole. CAS Number: 3613-73-8. Synonyms: Dimebon(TM), Latrepirdine. Molecular Formula: C21H25N3. Formula Weight: 319.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 1 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml. SMILES: CC1=CC=C(N(CCC2=CC=C(C)N=C2)C3=C4CN(C)CC3)C4=C1. InChi Code: InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3. InChi Key: JNODQFNWMXFMEV-UHFFFAOYSA-N.