Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B. Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.Formal Name: 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester. CAS Number: 632-93-9. Synonyms: DDC, 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine, NSC 8910, NSC 49528. Molecular Formula: C14H21NO4. Formula Weight: 267.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2), (1:7): 0.125 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 233, 350 nm. SMILES: CC1C(C(OCC)=O)=C(C)NC(C)=C1C(OCC)=O. InChi Code: InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3. InChi Key: CDVAIHNNWWJFJW-UHFFFAOYSA-N.